Modeling Pseudomonas aeruginosa pathogenesis in plant hosts

Pseudomonas aeruginosa – Pathogenesis and Pathogenic Mechanisms

Pseudomonas aeruginosa is a common bacterium, Gram-negative opportunistic pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease. It is one of the leading pathogen associated with nosocomial infections. It has a vast arsenal of pathogenicity factors that are used to interfere with host defenses. Pathogenesis in P. aeruginosa facilitates adhes...

Targeting mechanisms of Pseudomonas aeruginosa pathogenesis.

Pseudomonas aeruginosa is an opportunistic pathogen responsible for ventilator-acquired pneumonia, acute lower respiratory tract infections in immunocompromised patients and chronic respiratory infections in cystic fibrosis patients. High incidence, infection severity and increasing resistance characterize P. aeruginosa infections, highlighting the need for new therapeutic options. One such opt...

Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

We used plants as an in vivo pathogenesis model for the identification of virulence factors of the human opportunistic pathogen Pseudomonas aeruginosa. Nine of nine TnphoA mutant derivatives of P. aeruginosa strain UCBPP-PA14 that were identified in a plant leaf assay for less pathogenic mutants also exhibited significantly reduced pathogenicity in a burned mouse pathogenicity model, suggesting...

Modeling Pseudomonas aeruginosa biofilm detachment

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Parallels in fungal pathogenesis on plant and animal hosts.